Department of Biology

Dr. Elliot AltmanALTMAN
Professor

Director, Interdisciplinary Molecular Biosciences Ph.D. Program

CONTACT: 
Email:    Elliot.Altman@mtsu.edu
Phone:   (615 )494-8681
Fax:       (615) 898-5093

Office Location:
Jones Hall 155
Box 60
Murfreesboro, TN 37132

EDUCATION:
Ph.D. in Biology, June 1991, California Institute of Technology
B.S. in Chemistry, June 1980, Texas A&M University (Magna Cum Laude)
B.S. in Zoology, December 1979, Texas A&M University (Magna Cum Laude)

RESEARCH INTERESTS:
Metabolic Engineering - augmentation of biochemical pathways via the overproduction and/or removal of key metabolic enzymes to produce important industrial biochemicals

Peptide Therapeutics - creating peptide drugs by the improvement of naturally occurring peptides and the discovery of new peptides via combinatorial libraries

 

PUBLICATIONS:
Zhu, Y., Eiteman, M. A., Lee, S. A., and Altman, E. 2010. Conversion of glycerol to pyruvate by Escherichia coli using an acetate- and glucose-limited fed-batch process. Journal of Industrial Microbiology and Biotechnology. 37:307-312.

Lu, S., Eiteman, M. A., and Altman, E. 2010. Effect of flue gas components on succinate production and CO 2 fixation by metabolically engineered Escherichia coli. World Journal of Microbiology and Biotechnology. 26:429-435.

Lu, S., Eiteman, M. A., and Altman, E. 2009. Effect of CO 2 on succinate production in dual-phase Escherichia coli fermentations. Journal of Biotechnology. 143:213-223.

Lu, S., Eiteman, M. A., and Altman, E. 2009. pH and base counterion affect succinate production in dual-phase Escherichia coli fermentations. Journal of Industrial Microbiology and Biotechnology . 36:1101-1109.

Eiteman, M. A., Lee, S. A., Altman, R., and Altman, E . 2009. A substrate-selective co-fermentation with Escherichia coli produces lactate by simultaneously consuming xylose and glucose. Biotechnology and Bioengineering. 102: 822-827.

Singer, A., Eiteman, M. A., and Altman, E. 2009. DNA plasmid production in different host strains of Escherichia coli. Journal of Industrial Microbiology and Biotechnology . 36:521-530.

Altman, E. and Eiteman, M. A. 2009. The potential for using Escherichia coli and other organisms to produce recombinant ingredients for the cosmetic industry. In Microorgansims and Cosmetics, Anthony O'Lenick Jr.(ed.)., Allured Books, Carol Stream, IL., pp. 385-394.

Zhu, Y., Eiteman, M. A., Altman, R., and Altman, E. 2008. High glycolytic flux improves pyruvate production by metabolically engineered Escherichia coli. Applied and Environmental Microbiology. 74:6649-6655.

Zhu, Y., Eiteman, M. A., and Altman, E. 2008. Indirect monitoring of acetate exhaustion and cell recycle improve lactate production by non-growing Escherichia coli. Biotechnology Letters. 11:1943-1946.

Eiteman, M. A., Lee, S. A., and Altman, E . 2008. A co-fermentation strategy to consume sugar mixtures effectively. Journal of Biological Engineering. 2:1-8.

Zhu, Y., Eiteman, M. A., DeWitt, K. and Altman, E. 2007. Homolactate fermentation by metabolically engineered Escherichia coli. Applied and Environmental Microbiology. 73:456-464.

Eiteman, M. A. and Altman, E. 2006. Overcoming acetate in Escherichia coli recombinant protein fermentations. Trends in Biotechnology. 24: 530-536.

Smith, G. M., Lee, S. A., Reilly, K. C., Eiteman, M. A., and Altman, E. 2006. Fed-batch two-phase production of alanine by metabolically engineered Escherichia coli. Biotechnology Letters. 28:1695-1700.

Vemuri, G. N. , Eiteman, M. A., and Altman, E . 2006. Increased recombinant protein production in Escherichia coli strains with overexpressed water-forming NADH oxidase and a deleted ArcA regulatory protein. Biotechnology and Bioengineering. 94 : 538-542.

Vemuri, G. N. , Altman, E., Sangurdekar, D. P., Khodursky, A. B ., and Eiteman , M. A. 2006. Overflow metabolism in Escherichia coli during steady-state growth: transcriptional regulation and the effect of redox. Applied and Environmental Microbiology. 72: 3652-3661.

Vemuri, G. N., Minning, T. A., Altman, E., and Eiteman, M. A. 2005. Physiological response of central metabolism in Escherichia coli to deletion of pyruvate oxidase and introduction of heterologous pyruvate carboxylase. Biotechnology and Bioengineering . 90 :64-76.

Walker, J. R. and Altman, E. 2005. Biotinylation facilitates the uptake of large peptides by Escherichia coli and other Gram-negative bacteria. Applied and Environmental Microbiology. 71:1850-1855.

Lee, M., Smith, G. M., Eiteman, M. A., and Altman, E. 2004. Aerobic production of alanine by Escherichia coli aceF ldhA mutants expressing the Bacillus sphaericus alaD gene. Applied Microbiology and Biotechnology . 65:56-60.

Tomar, A. C., Eiteman, M. A., and Altman, E. 2003. The effects of acetate pathway mutants on the production fo pyruvate in Escherichia coli. Applied Microbiology and Biotechnology. 62:76-82.

Walker, J. R., Altman, R. K., Warren, J., and Altman, E. 2003. Using protein-based motifs to stabilize peptides. Journal of Peptide Research. 62:214-226.

Xie, L., Eiteman, M. A., and Altman, E. 2003. Production of aminolevulinic acid by an Escherichia coli aminolevulinate dehydratase mutant strain that overproduces Rhodobacter sphaeroides aminolevulinate synthase. Biotechnology Letters. 25 :1751-1755.

Xie, L., Hall, D., Eiteman, M. A., and Altman, E. 2003. Optimization of aminolevulinate synthase production in Escherichia coli using factorial design. Applied Microbiology and Biotechnology. 63:267-273.

March, J. C., Eiteman, M. A., and Altman, E. 2002. Expression of anaplerotic enzyme pyruvate carboxylase improves recombinant protein expression in Escherichia coli. Applied and Environmental Microbiology. 68:5620-5624.

Vemuri, G. N., Eiteman, M. A., and Altman, E. 2002. Succinate production in dual-phase Escherichia coli fermentations depends on the time of transition from aerobic to anaerobic conditions. J. Industrial Microbiology and Biotechnology. 28:325-332.

Vemuri, G. N., Eiteman, M. A., and Altman, E. 2002. Effects of growth mode and pyruvate carboxylase on succinic acid production by metabolically engineered strains of Escherichia coli. Applied and Environmental Microbiology. 68:1715-1727.

Gokarn, R. R., Evans, J. D., Walker, J. R., Martin, S. A., Eiteman, M. A., and Altman, E. 2001. The physiological effects and metabolic alterations caused by the expression of Rhizobium etli pyruvate carboxylase in Escherichia coli. Applied Microbiology and Biotechnology. 56:188-195.

Walker, J. R., Roth, J. R., and Altman, E. 2001. An in vivo study of novel bioactive peptides that inhibit the growth of Escherichia coli. Journal of Peptide Research. 58:380-388.

Xie, L., Lee, S. A., Hanel, B. M., Eiteman, M. A., and Altman, E. 2001. Anaerobic fermentation of Salmonella typhimurium with and without pyruvate carboxylase. Biotechnology Letters. 23:111-117.

Gokarn, R. R., Eiteman, M. A. and Altman, E. 2000. Metabolic Analysis of Escherichia coli in the Presence and Absence of Carboxylating Enzymes: Phosphoenolpyruvate Carboxylase and Pyruvate Carboxylase. Applied and Environmental Microbiology. 66:1844-1850.

Walker, J. R., Warren, J. and Altman, E. 2000. An intracellular approach for generating stable synthetic peptides and its potential applications. In Peptides for the New Milenium; Proceedings of the 16 th American Peptide Symposium, G.B. Fields, J.P. Tam, and G. Barany, (eds.), Kluwer Academic Publishers, Boston, pp. 262-263.

Warren, J., Walker, J. R., Roth, J. R., and Altman, E. 2000. Construction and characterization of a highly regulable expression vector, pLAC11, and its multipurpose derivatives, pLAC22 and pLAC33. Plasmid . 44:138-151.

Eiteman, M. A., Gokarn, R. R., and Altman, E. 1998. Metabolic engineering of E. coli to alter distribution of fermentation products. Proceedings of the Institute of Biological Engineering, 1:96-101.

Gokarn, R. R., Eiteman, M. A., and Altman, E. 1998. Expression of pyruvate carboxylase enhances succinate production in Escherichia coli without affecting glucose uptake. Biotechnology Letters. 20:795-798.

Altman, E., Roth, J. R., Hessel, A., and Sanderson, K. E. 1996. Transposons currently in use in genetic analysis of Salmonella. In Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology, 2nd edition, Neidhardt, F.C.(ed.), American Society for Microbiology, Washington, D.C., pp. 2613-2626.

Wild, J., Walter, W., Gross, C. A., and Altman, E. 1993. Accumulation of secretory protein precursors in Escherichia coli induces the heat shock response. Journal of Bacteriology. 175:3992-3997.

Wild, J., Altman, E., Yura, T., and Gross, C. A. 1992. DnaK and DnaJ heat shock proteins participate in protein export in Escherichia coli. Genes and Development. 6:1165-1172.

Altman, E., Kumamoto, C. A., and Emr, S. D. 1991. Heat-shock proteins can substitute for SecB function during protein export in Esherichia coli. European Molecular Biology Organization Journal. 10:239-245.

Altman, E., Bankaitis, V. A., and Emr. S. D. 1990. Characterization of a region in mature LamB protein that interacts with a component of the export machinery of Esherichia coli. Journal of Biological Chemistry. 265:18148-18153.

Altman, E., Emr, S. D., and Kumamoto, C. A. 1990. The presence of both the signal sequence and a region of mature LamB protein are required for the interaction of LamB with the export factor SecB. Journal of Biological Chemistry. 265:18154-18160.

Bankaitis, V. A., Altman, E., and Emr, S. D. 1986. Export and localization of Escherichia coli envelope proteins. In: Bacterial Outer Membranes As Model Systems, Inouye, M. (ed.), John Wiley & Sons, Inc. New York, pp. 75-116.

Altman, E., Young, K., Garrett, J., Altman, R., and Young, R. 1985. Subcellular localization of lethal lysis proteins of bacteriophages l and fX174. Journal of Virology. 53:1008-1011.

Altman, E., Altman, R. K., Garrett, J. M., Grimaila, R. J., and Young, R. 1983. S gene product: Identification and membrane localization of a lysis control protein. Journal of Bacteriology. 155:1130-1137.

 

PATENTS:

Bodie, N. M. and Altman, E. Methods for inhibiting immune complex formation in a subject. US Patent 7,786,258, issued August 31, 2010.

Eiteman, M. A., and Altman, E. Microbial production of pyruvate and pyruvate derivatives. US Patent 7,749,740, , issued July 6, 2010.

Bodie, N. M. and Altman, E. Methods for inhibiting immune complex formation in a subject. US Patent 7,714,104, issued May 11, 2010.

Altman, E. and Walker, J. R. Biotin-facilitated transport in gram negative bacteria. US Patent 7,601,511, issued October 13, 2009.

Bodie, N. M. and Altman, E. Inhibition of immune complex formation. US Patent 7,584,059, issued September 1, 2009.

Altman, E. Stabilized bioactive peptides and methods of identification, synthesis and use. US Patent 7,365,162, issued April 29, 2008.

Altman, E. Stabilized bioactive peptides and methods of identification, synthesis and use. US Patent 7,122,516, issued October 17, 2006.

Bodie, N. M. and Altman, E. Inhibition of immune complex formation. US Patent 6,916,904, issued July 12, 2005.

Altman, E. Stabilized bioactive peptides and methods of identification, synthesis and use. US Patent 6,818,611, issued November 16, 2004.

Gokarn, R. R., Eiteman, M. A., and Altman, E. Metabolically engineered E. coli for enhanced production of oxaloacetate-derived biochemicals. US Patent 6,455,284, issued September 24,2002.

PATENTS PENDING:

Bodie, N. M., Bodie, R., and Altman, E. Methods for treating immune mediated neurological diseases. US Patent Application 20090105138, published by the US Patent and Trademark Office on April 23, 2009.

Altman, E. Stabilized bioactive peptides and methods of identification, synthesis, and use. US Patent Application 20090004696, published by the US Patent and Trademark Office on January 1, 2009.

Bodie, N. M., Bodie, R., and Altman, E. Methods for treating Alzheimer's Disease. US Patent Application 20080207498, published by the US Patent and Trademark Office on August 28, 2008.

Bodie, N. M., Bodie, R., and Altman, E. Methods for treating Parkinson's Disease. US Patent Application 20080200392, published by the US Patent and Trademark Office on August 21, 2008.

Bodie, N. M., Bodie, R., and Altman, E. Methods for treating Amyotrophic Lateral Sclerosis. US Patent Application 20080187490, published by the US Patent and Trademark Office on August 7, 2008.

Vemuri, G., Eiteman, M. A. and Altman, E. Reduced overflow metabolism and methods of use. US Patent Application 20070249018, published by the US Patent and Trademark Office on October 25, 2007.

Bodie, N. M. and Altman, E. Methods for inhibiting immune complex formation in a subject. US Patent Application 20070225231, published by the US Patent and Trademark Office on September 27, 2007.

Altman, E. Stabilized bioactive peptides and methods of identification, synthesis, and use. US Patent Application 20030190740, published by the US Patent and Trademark Office on October 9, 2003.

Gokarn, R. R., Eiteman, M. A. and Altman, E. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals. US Patent Application 20030087381, published by the US Patent and Trademark Office on May 8, 2003.