<img height="224" width="200" alt="Dr. D. Andrew Burden " src="http://www.mtsu.edu/chemistry/images/burden.jpg" align="right" /><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;"><strong>CONTACT INFO:</strong><br /><br /> <span style="color:#333333;"><strong>E-mail:</strong></span> <a href="mailto:daburden@mtsu.edu">daburden@mtsu.edu</a><br /> <strong><span style="color:#333333;">Phone:</span></strong> (615) 904-8194</span><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;"><br /> <span style="color:#333333;"><strong>Office:</strong></span> Davis Science Bldg. 228F<br /> <strong><span style="color:#333333;">P.O. Box</span></strong>: 68</span>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;"><strong>EDUCATION/INTERESTS:</strong><br /><br /> (1999) Ph.D., University of Louisville (1993).</span> <span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">He is currently teaching CHEM 625 (focusing on protein structure and enzymology) and CHEM 325 Biochemistry. His research interests include the mechanism of action of the enzyme DNA topoisomerase II, as well as the mechanism of action of the diverse group of anticancer drugs which target this enzyme. Dr. Burden is currently a Special Fellow of the Leukemia Society of America, and has spent the past five years as a Research Fellow in the laboratory of Dr. Neil Osherhoff in the Dept. of Biochemistry at Vanderbilt University.</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">Dr. Burden enjoys music, reading, and military history ( particularly the American Civil War). He has two sons: Drew, age 8, and Cassidy, age 4.</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;"><strong>SELECTED PUBLICATIONS:</strong></span></p>
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<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">Wilson Byl, J.A., Fortune, J.M. Burden, D.A., Nitiss, J.L., Utsugi, T., Yamada, Y., and Osheroff, N. "DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancement", <em>Biochemistry</em> <strong>38</strong>, 15573-15579 (<strong>1999</strong>).</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">Kingma, P.S., Burden, D.A., and Osheroff, N. "Binding of Etoposide to Topoisomerase II in the Absence of DNA: Decreased Affinity as a Mechanism of Drug Resistance", <em>Biochemistry</em> <strong>38</strong>, 3457-3461 (<strong>1999</strong>).</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">Burden, D.A., and Osheroff, N. "In Vitro evolution of Preferred Topoisomerase II DNA Cleavage Sites", <em>J. Biol. Chem.</em> <strong>274</strong>, 5227-5235 (<strong>1999</strong>).</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">Burden D.A., Froelich-Ammon, S.J., and Osheroff, N. "Topoisomerase II-Mediated Cleavage of Plasmid DNA, " in Protocols for DNA Topoisomerases: II. Enzymology and Topoisomerase-Targeted Drugs, Bjornsti, M.A., and Osheroff, N. (eds.) Humana Press, Totowa, New Jersey, text in press.</span></p>
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