Chemistry Department

Dr. Paul C. Kline

Dr. Paul C. Kline CONTACT INFO:


Phone: (615)
Office: New Science Bldg.(SCI), Room 3079 
P.O. Box : X102


(1994) B.S., Christian Brothers College; M.S., Georgia Institute of Technology; Ph.D., University of Notre Dame; Postdoctoral, Albert Einstein College of Medicine. Bioorganic and Biophysical Chemistry: mechanistic enzymology and transition state analysis of enzyme-catalyzed reactions.


Kline, P.C.; Noll, B.C.; Zhao, H.; Serianni, A.S. 1-( b -D-Erythrofuranosyl)cytidine ( b -erythrocytidine). Acta Crystallographica Section C Crystal Structure Communications 2007, C63, 137-140.

Bates C.; Z. Kendrick Z.; McDonald, N; Kline, P. C. Transition State Analysis of Adenosine Nucleosidase from Yellow Lupin ( LupinuslLuteus). Phytochemistry 2006, 67, 5-12.

Hunt, C.; Gillani, N.; Farone, A.; Rezaei, M.; Kline, P.C. Kinetic Isotope Effects of Nucleoside Hydrolase from Escherichia coli. Biochim. Biophys. Acta Proteins and Proteomics 2005, 1751, 140-149.

Abusamhadneh, E.; McDonald, N. E.; Kline, P. C. Purification and characterization of adenosine nucleosidase form yellow lupin ( Lupinus luteus). Plant Sci. 2000, 153, 25-32.

Verdel, E. F.; Kline, P. C.; Wani, S.; Woods, A. E. Purification and partial characterization of haloperoxidase from fresh water algae Cladophora glomerata. Comp. Biochem. Physiol. B 2000, 125, 179-187.

Kline, P. C.; Razaei, M.; Lee, T. A. Determination of Kinetic Isotope Effects for Nucleoside Hydrolases using Gas Chromatography/Mass Spectrometry. Anal. Biochem. 1999, 275, 6-10.



Mansoureh Rezaei, "Transition State Analysis of Thymidine Phosphorylase from E. coli"; D.A. Dissertation 2001

Barbara J. Walton, "Selection, Modification, and Evaluation of Laboratory Experiments for a One-Semester Introductory Biochemistry Course" D.A. Dissertation 1998.

Nancy McDonald, "Characterization of Adenosine Nucleosidase from Lupinus Luteus" D.A. Dissertation 1998.


Michael Kearney, "Kinetic Isotope Effects of Thymidine Phosphorylase" M.S. Thesis 1998.

X. Liu, "Characterization of Adenosine Nucleosidase from Yellow Lupin Seeds" M.S. Thesis 1998.

Fariborz Rohakhtar, "Investigation of the Structure of a Stable Complex Between Purine Nucleoside Phosphorylase and Hypoxanthine," M.S. 1997.

E. Abusamhadneh, "Isolation and Characterization of Adenosine Nucleosidase from Yellow Lupin Seeds" M.S. Thesis 1997.


Technology Access Fee Grant, "Upgrade of Biochemistry Teaching Laboratories"; 2003, $170,000

American Chemical Society Petroleum Research Fund, "Transition State Analysis of Adenosine Nucleosidase" 1998-2000, $30,000.

P. C. Kline and A. Friedli, MTSU Technology Access Fees to purchase Gas Chromatographs for Undergraduate Organic and Biochemistry Laboratories. $40,000.