Dr. Anthony L. Farone

Professor

Dr. Anthony  L. Farone
615-898-5343
Room 2083, Science Building (SCI)
MTSU Box 60, Murfreesboro, TN 37132
Office Hours

On Demand

Degree Information

  • Ph.D., Miami University, Oxford, OH (1992)
  • M.S., Miami University, Oxford, OH (1988)
  • B.S., Pennsylvania State University (1984)

Areas of Expertise

  • Immunology
  • Microbiology
  • Immunomodulators

Biography

My laboratory group is interested in the inflammatory response in immune cells called macrophages. The inflammatory responses stimulated by macrophages are important to resolve infections but also result in many chronic conditions such as Rheumatoid Arthritis and Crohn's Disease. Our research objectives are two-fold: to characterize the interaction of human macrophages with microbes and to find new therapies that will regulate the inflammatory response.

I am a member of a group of res...

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My laboratory group is interested in the inflammatory response in immune cells called macrophages. The inflammatory responses stimulated by macrophages are important to resolve infections but also result in many chronic conditions such as Rheumatoid Arthritis and Crohn's Disease. Our research objectives are two-fold: to characterize the interaction of human macrophages with microbes and to find new therapies that will regulate the inflammatory response.

I am a member of a group of researchers at MTSU that comprise the Tennessee Center for Botanical Medicine. We are located in the departments of Biology, Chemistry and Agriscience. Our faculty work together to isolate and characterize novel botanicals and modify existing natural compounds that have anti-cancer, anti-viral, anti-parasitic, as well as anti-inflammatory activity.

Grants

  • NSF Innovation-Corps Grant, Biopanel, (2016-2017) co-PIs: Brock Arivett and Elliot Altman ($50,000)
  • NSF I-Corps Grant, Salomon's House, (2015-2016) co-PIs Matt Wright and Elliot Altman ($50,000)
  • MTSU Clean Energy Grant. 2011-2017. Co-PI. Bioremediation of Barbital Compounds for Eco-Friendly Composting ($32,000). Co-PIs: M. Farone (Biology) and P. Kline (Chemistry).
  • NSF GK-12 Grant International Supplement. 2013-2016. PI. TRIAD: Reforming Graduate Education through Teaching, Research, and Industry Applications to Deepen Scientific Understanding. Co-PIs: M. Farone (MTSU Biology), K. Sadler with Universidad de Chile, Santiago and University of Puerto Rico ($75,000).
  • NSF GK-12 Grant. 2009-2016. PI. TRIAD: Reforming Graduate Education through Teaching, Research, and Industry Applications to Deepen Scientific Understanding ($3,000,000). Co-PIs: M. Farone (MTSU Biology), K. Sadler (MTSU Biology Education) and E. Myles (TSU Biology).

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Publications

  • Mehari YT, Arivett BA, Farone AL, Gunderson JH, Farone MB. 2016. Draft genome sequences of two novel amoeba-resistant intranuclear bacteria, “Candidatus Berkiella cookevillensis” and “Candidatus Berkiella aquae.” Genome Announc 4: pii: e01732-15. doi: 10.1128/genomeA.01732-15. PubMed PMID: 26893424; PubMed Central PMCID: PMC4759071.
  • Mehari YT, Hayes BJ, Redding, KS*, Mariappan PV, Gunderson JH, Farone AL, Farone MB. 2016. Description ...
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  • Mehari YT, Arivett BA, Farone AL, Gunderson JH, Farone MB. 2016. Draft genome sequences of two novel amoeba-resistant intranuclear bacteria, “Candidatus Berkiella cookevillensis” and “Candidatus Berkiella aquae.” Genome Announc 4: pii: e01732-15. doi: 10.1128/genomeA.01732-15. PubMed PMID: 26893424; PubMed Central PMCID: PMC4759071.
  • Mehari YT, Hayes BJ, Redding, KS*, Mariappan PV, Gunderson JH, Farone AL, Farone MB. 2016. Description of “Candidatus Berkiella aquae”and “Candidatus Berkiella cookevillensis,” two intranuclear bacteria of freshwater amoebae. Int J Syst Evol Microbiol. 66:536-541. doi: 10.1099/ijsem.0.0007500.1099/ijsem.0.000750.
  • Park, H, Vick, E, Gao, Y, He, C, Almosnid, N, Farone, M, Farone, A. 2016. Cis and trans-gnetin H isolated from Paeonia suffruticosa exerts anti-inflammatory effects in human THP-1 cells. Submission to J Ethnopharmacology. 189:202–9. doi:10.1016/j.jep.2016.05.042
  • Gao, Y., Huang, R., Gong, Y., Park, H. S., Wen, Q., Almosnid, N., Uma, D., Chippada-Venkata, U. D., Hosain, N., Vick, E., Farone, A., E. Altman. 2015. The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells. Oncotarget. 6(27):24304-24319. doi:  10.18632/oncotarget.4475
  • Eric J. Vick, Hyo S. Park, Krista A. Huff, Kenneth M. Brooks, Anthony L. Farone, Mary B. Farone. 2014. Gardnerella vaginalis triggers NLRP3 inflammasome recruitment in THP-1 monocytes. J Reproductive Immunol. 106:67-75.
  • Pellizzaro, A., Farone, A. Farone, M., Mushi, R. Aguinaga, M., and D. Erenso.2012. Direct laser trapping for measuring the behavior of transfused erythrocytes in a sickle cell anemia patient. Biomed Optics Express. 3:2190-2199.
  • Jackson, J., Farone, A., and M. Farone. 2011. Bacterial enteropathogens associated with diarrhea in a rural population of Haiti [ID 23426]. Res Rep Trop Med. 2:129-133.
  • Farone, A., Farone, M., Kline, P., and Z. Sinkala. 2010. A practical approach for computing the active site of the ribonucleoside hydrolase of E.coli encoded by rihC. Adv Exp Med Biol. 680:437-443.
  • Farone, A., Farone, M., Khaliq, A., Kline, P., Quinn, T., and Z. Sinkala, 2009. Identifying the active site of ribonucleoside hydrolase of E. coli encoded by RihC. Proceedings of the 2009 International Conference on Bioinformatics & Computational Biology: BIOCOMP2009 Vol. I, Editors: H.R. Arabnia and M. Q. Yang, CSREA Press, USA, pp 216-218.
  • Ward, R.L., McNeal, M.M., Farone, M.B., and A.L. Farone. 2007. "The Reoviridae" In: The Mouse in Biomedical Research. (A. Smith, ed.) 2nd Edition. Elsevier Scientific Publishing, Inc., New York. pp. 235-268.
  • Berk, S.G., Gunderson, J.H., Newsome A.L., Farone, A.L., Skolasinski, W.S., Hayes, B.J., Redding, K.S., Uddin, N., William, E.L., Reid, A., Ventrice, J.A., Skimmyhorn, J. and Farone, M. B. 2006. Occurrence of infected amoebae in cooling towers environments compared with natural aquatic environments: implications for emerging diseases. Environ. Sci. Technology 40:7440-7444.
  • Farone, A. L., O'Donnell, S.M., Brooks, C. S., Young, K. M., Pierce, J., Wetzel, D., Dermody, T. S. and Farone, M. B. 2006. Reovirus serotype-dependent inflammatory cytokine repsonses and replication patterns in a human monocyte cell line. Viral Immunol. 19:546-557
  • Farone, A. L., Farone, M. B., McNeal, M., Ward, R. Reoviridae and Epizootic Diarrhea of Infant Mice. 2006. In: The Mouse in Biomedical Research, 2nd Edition, J.G. Fox, C. Newcomer, A. Smith, S. Barthold, F. Quimby, M. Davisson, Eds. Academic Press, NY.
  • Hunt, C., Gillani, N., Farone, A., Rezaei, M. Kline, P. 2005. Kinetic isotope effects of nucleoside hydrolase from Escherichia coli. Biochimica et Biophysica Acta 1751, 140-149.
  • Farone, M., and Farone, A. 2005. Detecting mold spores in school buildings: An exercise in biodiversity. Am. Biol. Teach. 67: 401-410.

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Awards

  • 1996-2017 Official recognition every year by a graduating MTSU senior as "Someone Who Made a Difference"
  • 2009-2010 MTSU Excellence in Presentations
  • 2008-2009 MTSU Million Dollar Grantsmanship Award
  • 2006-2007 MTSU Research Mentor Award

Courses

Immunology (Biol 4300, FSBI 4300, Biol 6380)