Dr. April Weissmiller

Assistant Professor

Dr. April Weissmiller
(615) 898-5868
Room 2010, Science Building (SCI)
MTSU Box 60, Murfreesboro, TN 37132

Degree Information

  • PHD, University of California, San Diego (2013)
  • MS, Stanford University (2010)
  • BS, San Diego State University (2007)

Areas of Expertise

My research group focuses on unraveling how the oncogenic transcription factor MYC accesses and uses members of chromatin regulatory complexes to drive target gene expression. Our overall approach involves a combination of genetic, genomic, molecular, and biochemical experiments that allow high temporal resolution to identify the primary functions that these interactions play, while also determining how any direct changes result in downstream secondary functional consequences. Specifically, w...

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My research group focuses on unraveling how the oncogenic transcription factor MYC accesses and uses members of chromatin regulatory complexes to drive target gene expression. Our overall approach involves a combination of genetic, genomic, molecular, and biochemical experiments that allow high temporal resolution to identify the primary functions that these interactions play, while also determining how any direct changes result in downstream secondary functional consequences. Specifically, we are interested in dissecting the role that members of the SWI/SNF chromatin remodeling and histone methyltransferase complexes play in regulating MYC-driven transcriptional programs in two rare pediatric cancers thematically tied together by overt MYC deregulation: malignant rhabdoid tumor (MRT) and N-MYC amplified neuroblastoma. It is the goal of our research that the basic biology we uncover here will be used to drive translationally applicable research within my laboratory and open up new therapeutic avenues.

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Publications

Woodley CM, Romer AS, Wang J, Guarnaccia AD, Elion DL, Maxwell JN, Guerrazzi K, McCann TS, Popay TM, Matlock BK, Flaherty DK, Lorey SL, Liu Q, Tansey WP, Weissmiller AM (2021) Multiple interactions fo the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler. Oncogene. April 30, Epub ahead of Print

Guarnaccia AD, Rose KL, Wang J, Zhao B, Popay TM, Wang CE, Guerrazzi K, Hill S, Woodley CM, Hansen TJ, Lorey SL, Shaw JG, Payne WG, Weissmiller AM, O...

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Woodley CM, Romer AS, Wang J, Guarnaccia AD, Elion DL, Maxwell JN, Guerrazzi K, McCann TS, Popay TM, Matlock BK, Flaherty DK, Lorey SL, Liu Q, Tansey WP, Weissmiller AM (2021) Multiple interactions fo the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler. Oncogene. April 30, Epub ahead of Print

Guarnaccia AD, Rose KL, Wang J, Zhao B, Popay TM, Wang CE, Guerrazzi K, Hill S, Woodley CM, Hansen TJ, Lorey SL, Shaw JG, Payne WG, Weissmiller AM, Olejniczak ET, Fesik SW, Liu Q, and Tansey WP (2021). Impact of WIN site inhibitor on the WDR5 interactome. Cell Reports. Jan 19;34(3):108636.

Popay TM, Wang J, Adams CM, Codreanu SG, Sherrod S, McClean JA, Thomas LR, Lorey SL, Machida YJ, Weissmiller AM, Eischen CM, Liu Q, and Tansey WP (2021). MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1. ELife. Jan 8;10:e60191

Bryan AF, Wang J, Howard GC, Guarnaccia AD, Woodley CM, Aho ER, Rellinger EJ, Matlock BK, Flaherty DK, Lorey SL, Chung DH, Fesik SW, Liu Q, Weissmiller AM, Tansey WP (2020). WDR5 is a conserved regulator of protein synthesis gene expression. Nucleic Acids Res. 2020 Apr 6;48(6): 2924-2941.

Thoma LR, Adams CM, Wang J, Weissmiller AM, Creighton J, Lorey SL, Liu Q, Fesik SW, Eischen CM, and Tansey WP (2019) Interaction of the oncoprotein transcription factor MYC with its chromatin co-factor WDR5 is essential for tumor maintenance. Proc. Natl. Acad. Sci. USA. Dec 10;116(50):25260-25268. 

Aho ER, Weissmiller AM, Fesik SW, Tansey WP. (2019) Targeting WDR5: A WINning Anti- Cancer Strategy? Epigenetic Insights. Jul 18;12:2516865719865282.

Weissmiller AM, Wang J, Lorey SL, Howard GC, Martinez, E, Liu Q, Tansey WP. (2019) Inhibition of MYC by the SMARCB1 tumor suppressor. Nature Communications. May 1;10(1):2014.

Aho ER, Wang J, Gogliotti RD, Howard GC, Phan J, Acharya P, Macdonald JD, Cheng K, Lorey SL, Lu B, Wenzel S, Foshage AM, Alvarado J, Wang F, Shaw JG, Zhao B, Weissmiller AM, Thomas LR, Vakoc CR, Hall MD, Hiebert SW, Liu Q, Stauffer SR, Fesik SW, Tansey WP (2019) Displacement of WDR5 from chromatin by a WIN site inhibitor with picomolar affinity. Cell Reports. Mar 12;26(11):2916-2928.e13.

 

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Awards

2020-2022 Rally Foundation for Childhood Cancer Young Investigator Award

2019 Vanderbilt-Ingram Cancer Center Post Doc of the Year

2019 Vanderbilt Cell and Developmental Biology Post Doc of the Year

2017-2020 Rally Foundation for Childhood Cancer Research and Open Hands Overflowing Hearts Co-funded Fellowship

2016-2017 Rally Foundation for Childhood Cancer Research Fellowship

2016-2017 AACR Basic Cancer Research Fellowship

Courses

BIOL 3250 Genetics

BIOL 4450/6450 Molecular Genetics