Faculty and Staff

Dr. Paul C. Kline

Professor

Dr. Paul C. Kline
615-898-5466
Room 3079, Science Building (SCI)
MTSU Box X102, Murfreesboro, TN 37132

Degree Information

  • Ph.D., University of Notre Dame (1992)
  • M.S., Georgia Institute of Technology (1983)
  • B.S., Christian Brothers University (1979)
  • B.S., Christian Brothers University (1979)

Areas of Expertise

  • Bioorganic and Biophysical Chemistry
  • Mechanistic Enzymology and Transition State Analysis of Enzyme-Catalyzed Reactions
  • Compound purification, identification and synthesis

Publications

  • Kline, P.C.; Noll, B.C.; Zhao, H.; Serianni, A.S. 1-( b -D-Erythrofuranosyl)cytidine ( b -erythrocytidine). Acta Crystallographica Section C Crystal Structure Communications 2007, C63, 137-140.
  • Bates C.; Z. Kendrick Z.; McDonald, N; Kline, P. C. Transition State Analysis of Adenosine Nucleosidase from Yellow Lupin ( LupinuslLuteus). Phytochemistry 2006, 67, 5-12.
  • Hunt, C.; Gillani, N.; Farone, A.; Rezaei, M.; Kline, P.C. Kinetic Isotope Effects of Nucleoside Hydrola...
Read More »
  • Kline, P.C.; Noll, B.C.; Zhao, H.; Serianni, A.S. 1-( b -D-Erythrofuranosyl)cytidine ( b -erythrocytidine). Acta Crystallographica Section C Crystal Structure Communications 2007, C63, 137-140.
  • Bates C.; Z. Kendrick Z.; McDonald, N; Kline, P. C. Transition State Analysis of Adenosine Nucleosidase from Yellow Lupin ( LupinuslLuteus). Phytochemistry 2006, 67, 5-12.
  • Hunt, C.; Gillani, N.; Farone, A.; Rezaei, M.; Kline, P.C. Kinetic Isotope Effects of Nucleoside Hydrolase from Escherichia coli. Biochim. Biophys. Acta Proteins and Proteomics 2005, 1751, 140-149.
  • Abusamhadneh, E.; McDonald, N. E.; Kline, P. C. Purification and characterization of adenosine nucleosidase form yellow lupin ( Lupinus luteus). Plant Sci. 2000, 153, 25-32.
  • Verdel, E. F.; Kline, P. C.; Wani, S.; Woods, A. E. Purification and partial characterization of haloperoxidase from fresh water algae Cladophora glomerata. Comp. Biochem. Physiol. B 2000, 125, 179-187.
  • Kline, P. C.; Razaei, M.; Lee, T. A. Determination of Kinetic Isotope Effects for Nucleoside Hydrolases using Gas Chromatography/Mass Spectrometry. Anal. Biochem. 1999, 275, 6-10.

« Read Less

Awards

Grants

  • Technology Access Fee Grant, "Upgrade of Biochemistry Teaching Laboratories"; 2003, $170,000
  • American Chemical Society Petroleum Research Fund, "Transition State Analysis of Adenosine Nucleosidase" 1998-2000, $30,000.
  • P. C. Kline and A. Friedli, MTSU Technology Access Fees to purchase Gas Chromatographs for Undergraduate Organic and Biochemistry Laboratories. $40,000.

Research/Scholarly Activity

Directed Dissertations

  • Mansoureh Rezaei, "Transition State Analysis of Thymidine Phosphorylase from E. coli"; D.A. Dissertation 2001
  • Barbara J. Walton, "Selection, Modification, and Evaluation of Laboratory Experiments for a One-Semester Introductory Biochemistry Course" D.A. Dissertation 1998.
  • Nancy McDonald, "Characterization of Adenosine Nucleosidase from Lupinus Luteus" D.A. Dissertation 1998.

Theses

... Read More »

Directed Dissertations

  • Mansoureh Rezaei, "Transition State Analysis of Thymidine Phosphorylase from E. coli"; D.A. Dissertation 2001
  • Barbara J. Walton, "Selection, Modification, and Evaluation of Laboratory Experiments for a One-Semester Introductory Biochemistry Course" D.A. Dissertation 1998.
  • Nancy McDonald, "Characterization of Adenosine Nucleosidase from Lupinus Luteus" D.A. Dissertation 1998.

Theses

  • Michael Kearney, "Kinetic Isotope Effects of Thymidine Phosphorylase" M.S. Thesis 1998.
  • X. Liu, "Characterization of Adenosine Nucleosidase from Yellow Lupin Seeds" M.S. Thesis 1998.
  • Fariborz Rohakhtar, "Investigation of the Structure of a Stable Complex Between Purine Nucleoside Phosphorylase and Hypoxanthine," M.S. 1997.
  • E. Abusamhadneh, "Isolation and Characterization of Adenosine Nucleosidase from Yellow Lupin Seeds" M.S. Thesis 1997.

Grants

  • Technology Access Fee Grant, "Upgrade of Biochemistry Teaching Laboratories"; 2003, $170,000
  • American Chemical Society Petroleum Research Fund, "Transition State Analysis of Adenosine Nucleosidase" 1998-2000, $30,000.
  • P. C. Kline and A. Friedli, MTSU Technology Access Fees to purchase Gas Chromatographs for Undergraduate Organic and Biochemistry Laboratories. $40,000.

« Read Less